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Central metabolic pathways and the integration and control of metabolism

This set of exercises introduces pathways that are common to carbohydrate, lipid and amino acid metabolism - the central metabolic pathways. These pathways can be considered to be both catabolic, leading to ATP formation, and also anabolic, leading to synthesis and interconversion of metabolic substrates.

The following exercises are available in this section:

Experiments with isolated liver cells - the citric acid cycle and warming up post-operative patients (The citric acid (Krebs) cycle)

Selection of fuels for muscle contraction (Control of muscle fuel selection depending on intensity and duration of exercise)

Hyperammonaemic coma due to liver failure (Hyperammonaemic coma due to liver failure )

An unconscious child with keto-acidosis and a skin rash (Biotin and multiple carboxylase deficiency)

 

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Objectives

After working through these exercises you should be able to:

Describe the citric acid cycle, explain why fatty acids and ketone bodies can never be a substrate for gluconeogenesis

Explain how the intensity and duration of exercise affect the selection of fuels for muscle contraction

Explain how hyperammonaemia leads to loss of consciousness

Explain the metabolic consequences of biotin deficiency and failure of carboxylases