Metabolism
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An unconscious child with keto-acidosis and a skin rash
Objectives
At the end of the session you should be able to:
Describe the role of biotin in carboxylases and its attachment to the apoenzyme
Explain how a single genetic defect can lead to defective activity of multiple carboxylases
Explain how impaired activity of carboxylases can lead to ketosis even in the fed state