Metabolism
on-line - the virtual tutorial room
copyright © 2008 - 2014 David A Bender
Gout and hyperuricaemia - and anti-cancer drugs
Objectives
At the end of the session you should be able to:
Describe the synthesis and catabolism of purines
Describe in outline the renal handling of uric acid
Explain why inhibition of xanthine oxidase is effective for the treatment of gout
Explain how folic acid antimetabolites, glutamine analogues and mercaptopurine act to inhibit purine synthesis and are effective anti-cancer agents
Describe the regulation of purine synthesis and the importance of PRPP amidotransferase and the availability of phosphoribosyl pyrophosphate
Describe the process of purine salvage and explain the consequences of partial or more or less complete lack of hypoxanthine-guanine phosphoribosyltransferase