Metabolism
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Two very hyperketotic children
In a series
of experiments using isolated rat cardiomyocytes (heart muscle cells), the consumption
of oxygen was measured when various substrates were added. The figures below
show the consumption of oxygen when the cells were provided with 10 µmol
/L acetoacetate or beta-hydroxybutyrate as substrates (mean ± sd for
5 x replicate incubations).
| substrate | nmol oxygen consumed /min /mg protein |
| acetoacetate | 240 ± 4 |
| beta-hydroxybutyrate | 270 ± 3 |