Metabolism
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Gripping abdominal pain and jaundice
Objectives
By the end of this exercise you should be able to:
Explain how liver disease and obstruction of the bile duct can lead to jaundice, and how these two causes of jaundice can be differentiated by a simple blood test
Describe the composition of bile and explain how gall stones are formed
Describe in outline the biosynthesis of the primary and secondary bile salts, and the entero-hepatic circulation of bile salts
Describe the role of bile salts in lipid digestion and absorption
Explain how inhibition of bile salt reabsorption can reduce serum cholesterol