Metabolism on-line - the virtual tutorial roomlogo

 

copyright © 2008 - 2015 David A Bender

Life-threatening acidosis in an alcoholic - and in a hunger striker given intravenous glucose

Key points from this exercise:

Thiamin, as thiamin diphosphate, is required for the oxidation of pyruvate. In thiamin deficiency there is (potentially life-threatening) acidosis due to elevated plasma concentrations of lactate and pyruvate, especially after a glucose load and moderate exercise.

Pyruvate is oxidised to acetyl CoA by a multi-enzyme complex, in which the following sequence of reactions occurs:

 

End of this exercise