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Life-threatening acidosis in an alcoholic - and in a hunger striker given intravenous glucose

Key points from this exercise:

Thiamin, as thiamin diphosphate, is required for the oxidation of pyruvate. In thiamin deficiency there is (potentially life-threatening) acidosis due to elevated plasma concentrations of lactate and pyruvate, especially after a glucose load and moderate exercise.

Pyruvate is oxidised to acetyl CoA by a multi-enzyme complex, in which the following sequence of reactions occurs:


End of this exercise